Last update
3/31/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.8
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
We explored the effects of mecobalamin, a form of B12, on carpal tunnel syndrome (CTS) in patients who have experienced a stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
Read More
7
Vitamin B12's effects on nerves
We examined how high doses of methylcobalamin, a form of vitamin B12, might improve conditions like carpal tunnel syndrome. Although methylcobalamin shows potential benefits for peripheral nerve conditions, our findings suggest that while it may help alleviate symptoms, the exact mechanisms remain unclear.
We highlighted both animal and human studies that suggest it can positively impact nerve health. However, further research is needed to fully understand its effectiveness and mechanisms.
We highlighted both animal and human studies that suggest it can positively impact nerve health. However, further research is needed to fully understand its effectiveness and mechanisms.
Read More
4
Vitamin B12 and carpal tunnel syndrome
We explored how vitamin B12 can help manage carpal tunnel syndrome (CTS), a common condition affecting the wrist due to median nerve compression. Our findings indicate that while several conservative treatments exist, such as splints and pain relievers, the role of B12 specifically in alleviating CTS symptoms was noted among other options but not highlighted as distinctly effective.
Ultimately, surgery remains a key method for severe cases. However, the overall effectiveness of vitamin B12 as a treatment for CTS lacks significant evidence for its unique benefit.
Ultimately, surgery remains a key method for severe cases. However, the overall effectiveness of vitamin B12 as a treatment for CTS lacks significant evidence for its unique benefit.
Read More
Most Useful Reviews
10
No more numbness
10 people found this helpful
No more finger numbness! I was diagnosed with Carpal Tunnel Syndrome and began searching for solutions, which led me to this supplement. After about a week of taking it, I noticed the numbness in my fingertips diminishing, and a month later, it has completely disappeared. It’s worth noting that the Carpal Tunnel Syndrome was relatively mild.
Read More
6
Slightly improved
8 people found this helpful
It’s quite delicious and shows promising results. The taste is reminiscent of berries. I take about four 1000mg tablets daily. While they don’t dissolve easily under the tongue, I lightly chew them for better absorption. I noticed some improvement in the numbness in my hands due to Carpal Tunnel Syndrome.
Read More
9
Quick improvement
1 people found this helpful
Following a mild case of Carpal Tunnel Syndrome, I was prescribed B12 at the hospital. When the numbness recurred, life with a child prevented me from visiting the hospital, so I tried this supplement instead. To my surprise, my condition improved quite rapidly! The candy tastes like acerola and is easy to incorporate into my daily routine. I will definitely purchase it again.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.8
- All Researches
9
We examined the impact of needle Dao treatment on patients with carpal tunnel syndrome by comparing two groups. One received needle Dao, while the other was treated with braces and medication including B12.
After treatment, we noticed significant improvements in nerve function tests among those treated with needle Dao. Their sensory nerve conduction and action potentials showed marked enhancement.
In contrast, while the control group saw some improvement, it wasn’t as pronounced. Overall, our findings suggest that needle Dao may offer better clinical outcomes for carpal tunnel syndrome compared to conventional methods.
After treatment, we noticed significant improvements in nerve function tests among those treated with needle Dao. Their sensory nerve conduction and action potentials showed marked enhancement.
In contrast, while the control group saw some improvement, it wasn’t as pronounced. Overall, our findings suggest that needle Dao may offer better clinical outcomes for carpal tunnel syndrome compared to conventional methods.
Read More
9
We investigated various treatments for early-stage carpal tunnel syndrome to find what works best. Sixty patients were randomly assigned to three groups, with one receiving basic treatments like Vitamin B12, while others also used acupuncture or herbal therapies.
Although electromyography results showed no significant changes, those in the acupuncture and herbal therapy groups reported better pain relief than the basic treatment group. Their success rates were notably higher, indicating these alternative therapies may be very effective for managing symptoms.
Although electromyography results showed no significant changes, those in the acupuncture and herbal therapy groups reported better pain relief than the basic treatment group. Their success rates were notably higher, indicating these alternative therapies may be very effective for managing symptoms.
Read More
9
We explored the effects of mecobalamin, a form of B12, on carpal tunnel syndrome (CTS) in patients who have experienced a stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
Read More
8
We examined the effectiveness of a dietary supplement containing various nutrients—including vitamin B12—on patients with early carpal tunnel syndrome (CTS).
The study involved 36 patients, split into two groups: one receiving physical therapy alone and the other combining therapy with the supplement.
While the findings suggest that the integrator may aid in improving nerve conduction and symptom resolution, it’s crucial to note that the extent of benefit specifically attributable to the B12 component remains unclear.
The study involved 36 patients, split into two groups: one receiving physical therapy alone and the other combining therapy with the supplement.
While the findings suggest that the integrator may aid in improving nerve conduction and symptom resolution, it’s crucial to note that the extent of benefit specifically attributable to the B12 component remains unclear.
Read More
We explored the effectiveness of a dietary supplement featuring B12 along with several other compounds in treating carpal tunnel syndrome (CTS) for patients awaiting surgery.
Patients were divided into two groups: one received the supplement for 60 days while the other did not.
Results showed significant improvement in symptoms and pain for those taking the supplement, but other functional metrics didn’t show notable changes. Surgery is still seen as the most effective treatment for severe cases.
Patients were divided into two groups: one received the supplement for 60 days while the other did not.
Results showed significant improvement in symptoms and pain for those taking the supplement, but other functional metrics didn’t show notable changes. Surgery is still seen as the most effective treatment for severe cases.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
No more numbness
10 people found this helpful
No more finger numbness! I was diagnosed with Carpal Tunnel Syndrome and began searching for solutions, which led me to this supplement. After about a week of taking it, I noticed the numbness in my fingertips diminishing, and a month later, it has completely disappeared. It’s worth noting that the Carpal Tunnel Syndrome was relatively mild.
Read More
6
Slightly improved
8 people found this helpful
It’s quite delicious and shows promising results. The taste is reminiscent of berries. I take about four 1000mg tablets daily. While they don’t dissolve easily under the tongue, I lightly chew them for better absorption. I noticed some improvement in the numbness in my hands due to Carpal Tunnel Syndrome.
Read More
9
Quick improvement
1 people found this helpful
Following a mild case of Carpal Tunnel Syndrome, I was prescribed B12 at the hospital. When the numbness recurred, life with a child prevented me from visiting the hospital, so I tried this supplement instead. To my surprise, my condition improved quite rapidly! The candy tastes like acerola and is easy to incorporate into my daily routine. I will definitely purchase it again.
Read More
7
Very effective
1 people found this helpful
missusb really helps with my severe Carpal Tunnel Syndrome.
Read More
9
Effective treatment
Excellent for peripheral neuropathy sufferers. Taking it once a day, along with an NSAID, was sufficient to manage my peripheral neuropathy. I would also suggest a general multivitamin, as they provide a different form of B12 for various functions. However, I am concerned that these red cobalt-containing chewables might stain my teeth with long-term use. Nonetheless, yellow teeth and a small amount of money spent is a small price to pay for relief from Carpal Tunnel Syndrome. CONS: The pills are highly hygroscopic, absorbing water from the oil, so unless you add fresh moisture absorbers, the pills at the bottom may have partially dissolved.
Read More
Frequently Asked Questions
10
No more numbness
10 people found this helpful
No more finger numbness! I was diagnosed with Carpal Tunnel Syndrome and began searching for solutions, which led me to this supplement. After about a week of taking it, I noticed the numbness in my fingertips diminishing, and a month later, it has completely disappeared. It’s worth noting that the Carpal Tunnel Syndrome was relatively mild.
9
Quick improvement
1 people found this helpful
Following a mild case of Carpal Tunnel Syndrome, I was prescribed B12 at the hospital. When the numbness recurred, life with a child prevented me from visiting the hospital, so I tried this supplement instead. To my surprise, my condition improved quite rapidly! The candy tastes like acerola and is easy to incorporate into my daily routine. I will definitely purchase it again.
6
Slightly improved
8 people found this helpful
It’s quite delicious and shows promising results. The taste is reminiscent of berries. I take about four 1000mg tablets daily. While they don’t dissolve easily under the tongue, I lightly chew them for better absorption. I noticed some improvement in the numbness in my hands due to Carpal Tunnel Syndrome.
7
Very effective
1 people found this helpful
missusb really helps with my severe Carpal Tunnel Syndrome.
4
Vitamin B12 and carpal tunnel syndrome
We explored how vitamin B12 can help manage carpal tunnel syndrome (CTS), a common condition affecting the wrist due to median nerve compression. Our findings indicate that while several conservative treatments exist, such as splints and pain relievers, the role of B12 specifically in alleviating CTS symptoms was noted among other options but not highlighted as distinctly effective.
Ultimately, surgery remains a key method for severe cases. However, the overall effectiveness of vitamin B12 as a treatment for CTS lacks significant evidence for its unique benefit.
Ultimately, surgery remains a key method for severe cases. However, the overall effectiveness of vitamin B12 as a treatment for CTS lacks significant evidence for its unique benefit.
9
We examined the impact of needle Dao treatment on patients with carpal tunnel syndrome by comparing two groups. One received needle Dao, while the other was treated with braces and medication including B12.
After treatment, we noticed significant improvements in nerve function tests among those treated with needle Dao. Their sensory nerve conduction and action potentials showed marked enhancement.
In contrast, while the control group saw some improvement, it wasn’t as pronounced. Overall, our findings suggest that needle Dao may offer better clinical outcomes for carpal tunnel syndrome compared to conventional methods.
After treatment, we noticed significant improvements in nerve function tests among those treated with needle Dao. Their sensory nerve conduction and action potentials showed marked enhancement.
In contrast, while the control group saw some improvement, it wasn’t as pronounced. Overall, our findings suggest that needle Dao may offer better clinical outcomes for carpal tunnel syndrome compared to conventional methods.
7
Vitamin B12's effects on nerves
We examined how high doses of methylcobalamin, a form of vitamin B12, might improve conditions like carpal tunnel syndrome. Although methylcobalamin shows potential benefits for peripheral nerve conditions, our findings suggest that while it may help alleviate symptoms, the exact mechanisms remain unclear.
We highlighted both animal and human studies that suggest it can positively impact nerve health. However, further research is needed to fully understand its effectiveness and mechanisms.
We highlighted both animal and human studies that suggest it can positively impact nerve health. However, further research is needed to fully understand its effectiveness and mechanisms.
4
We explored the effectiveness of different treatments for carpal tunnel syndrome, focusing specifically on vitamin B12's role. In our study, we looked at 61 patients with a total of 99 affected hands and compared five treatment approaches. These included the use of vitamins B6 and B12, steroid injections, hand splints, and combinations of these methods.
After assessing each patient with electrodiagnostic studies before treatment and again after one and two months, we found that treatments involving hand splinting, local steroid injections, and combination therapies delivered better results when it came to sensory nerve conduction studies. Notably, vitamin B12 used alone did not show substantial benefits. In fact, the combined treatments that included steroid injections appeared to work faster and more effectively for relieving symptoms.
Overall, our findings suggest that relying solely on vitamin B12 for carpal tunnel syndrome is not sufficient. Instead, a combination approach, particularly involving steroid injections and splinting, seems to be a more effective conservative treatment option for this condition.
After assessing each patient with electrodiagnostic studies before treatment and again after one and two months, we found that treatments involving hand splinting, local steroid injections, and combination therapies delivered better results when it came to sensory nerve conduction studies. Notably, vitamin B12 used alone did not show substantial benefits. In fact, the combined treatments that included steroid injections appeared to work faster and more effectively for relieving symptoms.
Overall, our findings suggest that relying solely on vitamin B12 for carpal tunnel syndrome is not sufficient. Instead, a combination approach, particularly involving steroid injections and splinting, seems to be a more effective conservative treatment option for this condition.
7
We conducted an observational study focusing on how a combination of uridine monophosphate, folic acid, and vitamin B12 can help those with carpal tunnel syndrome, the most prevalent form of peripheral entrapment neuropathy.
After two months of treatment, 48 patients showed a significant decrease in their pain levels, dropping from an average score of 17.3 to 10.3. Most participants also ceased or reduced their use of pain medication.
While these promising results point to potential benefits, further research with a more robust trial is necessary to confirm these findings.
After two months of treatment, 48 patients showed a significant decrease in their pain levels, dropping from an average score of 17.3 to 10.3. Most participants also ceased or reduced their use of pain medication.
While these promising results point to potential benefits, further research with a more robust trial is necessary to confirm these findings.
References
- D'Orio M, De Vitis R, Taccardo G, Rocchi L, Ferrari F, et al. Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study. Acta Biomed. 2023;94:e2023050. 10.23750/abm.v94iS2.12513
- Kokubo R, Kim K. [Carpal Tunnel Syndrome:Diagnosis and Treatment]. No Shinkei Geka. 2021;49:1306. 10.11477/mf.1436204516
- Marvulli R, Ianieri G, De Venuto G, Falcicchio M, Gallo GA, et al. Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome. Endocr Metab Immune Disord Drug Targets. 2021;21:345. 10.2174/1871530320666200728152953
- Zhang KY, Yang Y, Xu SW, Shou Y, Jiang HR, et al. [A case-control study on the treatment of carpal tunnel syndrome with needle Dao]. Zhongguo Gu Shang. 2018;31:497. 10.3969/j.issn.1003-0034.2018.06.002
- Negrão L, Nunes P. Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies. Pain Manag. 2016;6:25. 10.2217/pmt.15.60
- Tanaka H. [Old or new medicine? Vitamin B12 and peripheral nerve neuropathy]. Brain Nerve. 2013;65:1077. PubMed
- Zhang CY, Wang YX. [Observation on therapeutic effects of acupuncture combined with TDP irradiation and chinese herbal steaming and washing therapy for treatment of carpal tunnel syndrome in early stage]. Zhongguo Zhen Jiu. 2009;29:708. PubMed
- Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K. Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients. J Neurol Sci. 2005;231:13. PubMed
- Di Geronimo G, Caccese AF, Caruso L, Soldati A, Passaretti U. Treatment of carpal tunnel syndrome with alpha-lipoic acid. Eur Rev Med Pharmacol Sci. 2009;13:133. PubMed
- Wu SF, Chan RC, Hsu TC. [Electrodiagnostic evaluation of conservative treatment in carpal tunnel syndrome]. Zhonghua Yi Xue Za Zhi (Taipei). 1991;48:125. PubMed
Data last updated:
